Searchable abstracts of presentations at key conferences in endocrinology

ea0041oc12.2 | Obesity | ECE2016

Female 5β-reductase knockout mice are protected from diet induced obesity, insulin resistance and glucose intolerance

Gathercole Laura , Chapman Matthew , Larner Dean , Klusonova Petra , Penning Trevor , Lavery Gareth , Odermatt Alex , Tomlinson Jeremy

Steroid hormones and bile acids are potent regulators of metabolic phenotype. The enzyme 5β-Reductase (AKR1D1) has a crucial role in bile acid synthesis and also generates 5β-reduced dihydrosteroid metabolites, regulating intra-cellular steroid availability though the clearance of cortisol, testosterone, androstenedione and progesterone. As AKR1D1 sits at the interface of bile acid synthesis and steroid metabolism, we have hypothesised that it plays a key role in met...

ea0038oc3.6 | Steroids and adrenal | SFEBES2015

Female 5β-reductase knockout mice are protected from diet induced obesity, insulin resistance, and glucose intolerance

Gathercole Laura , Chapman Matthew , Larner Dean , Klusonova Petra , Penning Trevor , Odermatt Alex , Lavery Gareth , Tomlinson Jeremy

Steroid hormones and bile acids are potent regulators of metabolic phenotype. The enzyme 5β-reductase (AKR1D1) has a crucial role in bile acid synthesis and also generates 5β-reduced dihydrosteroid metabolites, regulating intra-cellular steroid availability though the clearance of cortisol, testosterone, androstenedione, and progesterone. As AKR1D1 sits at the interface of bile acid synthesis and steroid metabolism, we have hypothesised that it plays a key role in me...

ea0037ep663 | Pituitary: basic and neuroendocrinology | ECE2015

Social stress promotes changes in local metabolism of glucocorticoids

Pacha Jiri , Klusonova Petra , Ergang Peter , Vodicka Martin , Mikulecka Anna , Zach Petr

Stressful experiences produce profound physiological and behavioural disturbances that may contribute to many psychiatric disorders. Stress activates HPA axis whose end products glucocorticoids modulate immune cells and cytokine activity. Local effect of glucocorticoids depends not only on its concentration but also on the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11HSD1), which amplifies intracellular glucocorticoid concentration by the conversion of inactive 11-de...

ea0049ep730 | Steroid metabolism + action | ECE2017

Gender specific metabolic phenotype in the 5β-reductase knockout mouse

Gathercole Laura , Klusonova Petra , Nikolaou Nikolaos , Hazlehurst Jonathan , Moolla Ahmad , Dempster Niall , Penning Trevor , Cox Roger , Odermatt Alex , Tomlinson Jeremy

Steroid hormones and bile acids are potent regulators of metabolism. The enzyme 5β-reductase (AKR1D1) has a crucial role in bile acid synthesis and also generates 5β-reduced dihydrosteroid metabolites, regulating intra-cellular steroid availability though the clearance of cortisol, testosterone, androstenedione, and progesterone. As AKR1D1 sits at the interface of bile acid synthesis and steroid metabolism, we have hypothesised that it plays a key role in metabolic h...